A Modified Method for Increasing Radiochemical Purity of I-125 for Radiopharmaceuticals

Iodine-125 (125I) is one of the radioisotopes widely used in radiopharmaceuticals for diagnosis and therapy various cancers. Recent reports indicate that there has been shortages world supply this radioiodine isotope. One absolute requirements good must meet radiochemical purity, which generally to be above 95 %, with an efficiency over 90 %. The previous investigation shows purity low does not requirement. In work, we aim at improving method by modifying Jones reductor-based method. modified includes reduction uniformization Zn particle sizes, compaction, performance process a closed flow. reductor converted impurities into products; case, iodate (IO3-) periodate (IO4-) were iodide (I-), so 125I product fulfills yielded high efficiency. investigation, was, first time, improved 99.24 % 97.98